drugset / Trial / NCT05897034
Combination Therapy Between Doxycycline, Pentoxifylline, and Nitazoxanide in Sexually Active Men
Phase 2/3
Not yet recruiting
100 enrolled
Tanta University
Mostafa Mahmoud Bahaa Clinical Pharmacy Department, Horus University, New Damietta, Egypt · collab
RandomizedParallel-groupDouble-blindTreatment
Summary
Bacterial sexually transmitted infections (STIs) have been steadily increasing in gay, bisexual, and other men who have sex with men (MSM) over the past 2 decades. While that trend started prior to the introduction of human immunodeficiency virus (HIV) pre-exposure prophylaxis (PrEP) in 2012, HIV PrEP has been associated with increases in sexual contacts and decreases in condom use with an resultant acceleration in the increase of bacterial STIs such as gonorrhea, syphilis, and chlamydia.
Timeline
- Start
- 2023-06-20
- Primary completion
- 2024-06-20
- Completion
- 2028-06-20
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Nitazoxanide | Other / unclassified | 500 mg | Oral |
| Comparator | Pentoxifylline | Small molecule | 400 mg | — |
| Comparator | Doxycycline | Small molecule | 100 mg | Oral |