drugset / Trial / NCT05922930

Study of TROP2 CAR Engineered IL15-transduced Cord Blood-derived NK Cells Delivered Intraperitoneally for the Management of Platinum Resistant Ovarian Cancer, Mesonephric-like Adenocarcinoma, and Pancreatic Cancer

NCT05922930 ↗

Phase 1/2 Suspended 51 enrolled M.D. Anderson Cancer Center
NaSingle-groupOpen-labelTreatment

Summary

To find the recommended dose of TROP2- CAR-NK given intraperitoneally (directly into the abdominal cavity) to patients with highgrade serous ovarian cancer that has not responded to previous treatment or is resistant to treatment.

Timeline

Start
2023-10-11
Primary completion
2027-10-15
Completion
2028-01-15

Outcome

Outcome not reported

Stopped: “PI Request”

Drugs

EvaluationDrugModalityDoseRoute
Subject TROP2-CAR-NK Cell therapy — Other
Background Cyclophosphamide Other / unclassified — Intravenous
Background Fludarabine Small molecule — Intravenous