drugset / Trial / NCT05929716

An Open-Label, Single Center Phase 2 Study of Magrolimab, Rituximab and Radiation as Bridging Strategy Before CAR T-Cell Therapy in Patients With Relapsed or Refractory Large B-cell Lymphoma

NCT05929716

Phase 2 Withdrawn M.D. Anderson Cancer Center
Non-randomizedSingle-groupOpen-labelTreatment

Summary

To evaluate the efficacy of the combination of magrolimab, rituximab, and radiation as bridging therapy in patients with relapsed or refractory LBCL who receive CAR T-Cell Therapy (CART).

Timeline

Start
2023-09-30
Primary completion
2026-03-01
Completion
2028-03-01

Drugs

EvaluationDrugModalityDoseRoute
Subject Magrolimab Monoclonal antibody Intravenous
Subject Rituximab Monoclonal antibody Intravenous