Drugs / Magrolimab
last change Mar 2026 re-read 2 minutes ago

Magrolimab

also known as Hu5F9-G4 · ONO-7913 · 5F9 · Mag

Monoclonal antibody targets CD47 via inhibition

Developed for
acute myeloid leukemia · myelodysplastic syndrome · colorectal cancer · cancer · head and neck squamous cell carcinoma · urothelial carcinoma · B-cell non-Hodgkin lymphoma · brain cancer
+22 more · castration-resistant prostate carcinoma · chronic lymphocytic leukemia/small lymphocytic lymphoma · classic Hodgkin lymphoma · diffuse large B-cell lymphoma · female breast carcinoma · follicular lymphoma · hematopoietic and lymphoid cell neoplasm · large B-cell lymphoma · malignant pancreatic neoplasm · mantle cell lymphoma · marginal zone lymphoma · mycosis fungoides · myeloid neoplasm · neoplasm · neuroblastoma · non-Hodgkin lymphoma · osteosarcoma · ovarian cancer · plasma cell myeloma · Sezary syndrome · triple-negative breast carcinoma · urinary bladder cancer
Investigated by
Gilead Sciences · National Cancer Institute (NCI) · M.D. Anderson Cancer Center · Ono Pharmaceutical Co., Ltd. · California Institute for Regenerative Medicine (CIRM) · Hoffmann-La Roche
+15 more · Acerta Pharma BV · Astex Pharmaceuticals, Inc. · AstraZeneca · City of Hope Medical Center · Gilead Sciences, Inc., GlaxoSmithKline plc, Seattle Genetics and Astellas · Insel Gruppe AG, University Hospital Bern · Merck KGaA, Darmstadt, Germany · Merck Sharp & Dohme LLC · Novartis Pharmaceuticals · Ranjana Advani · Swiss National Science Foundation · The Leukemia and Lymphoma Society · University of Bern · University of California, San Francisco · Uwe Platzbecker

Trials 36 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 115 trials
Phase 1 NCT05823480 Oct 2024 → Feb 2026 acute myeloid leukemia, myelodysplastic syndrome City of Hope Medical Center Withdrawn No outcome recorded
Phase 1 NCT05807126 Mar 2024 → Dec 2026 castration-resistant prostate carcinoma, female breast carcinoma National Cancer Institute (NCI) Withdrawn No outcome recorded
Phase 1 NCT05738161 Jun 2023 → Feb 2024 urothelial carcinoma Insel Gruppe AG, University Hospital Bern Withdrawn No outcome recorded
Phase 1 NCT05169944 Apr 2022 → Sep 2024 brain cancer University of California, San Francisco Completed No outcome recorded
Phase 1 NCT04599634 Dec 2021 → Mar 2024 chronic lymphocytic leukemia/small lymphocytic lymphoma, follicular lymphoma, mantle cell lymphoma, marginal zone lymphoma National Cancer Institute (NCI) Completed No outcome recorded
Phase 1 NCT06540261 Sep 2021 → Dec 2027 expected colorectal cancer Ono Pharmaceutical Co., Ltd. Active not recruiting No outcome recorded
Phase 1 NCT04751383 Aug 2021 → Sep 2024 neuroblastoma, osteosarcoma National Cancer Institute (NCI) Terminated No outcome recorded
Phase 1 NCT06532344 Jul 2021 → Dec 2026 expected malignant pancreatic neoplasm Ono Pharmaceutical Co., Ltd. Active not recruiting No outcome recorded
Phase 1 NCT04403308 Jul 2020 → Jan 2022 cancer Ono Pharmaceutical Co., Ltd. Completed No outcome recorded
Phase 1 NCT03922477 Oct 2019 → Nov 2020 acute myeloid leukemia Hoffmann-La Roche Terminated No outcome recorded
Phase 1/26 trials
Phase 1/2 NCT05367401 Dec 2024 → Oct 2029 acute myeloid leukemia, myelodysplastic syndrome Novartis Pharmaceuticals Withdrawn No outcome recorded
Phase 1/2 NCT04541017 Apr 2021 → Oct 2024 Sezary syndrome, mycosis fungoides National Cancer Institute (NCI) Terminated No outcome recorded
Phase 1/2 NCT04435691 Jul 2020 → Mar 2025 acute myeloid leukemia M.D. Anderson Cancer Center Terminated No outcome recorded
Phase 1/2 NCT03869190 Jun 2019 → Oct 2025 urinary bladder cancer, urothelial carcinoma Hoffmann-La Roche Completed No outcome recorded
Phase 1/2 NCT02953509 Nov 2016 → Mar 2024 non-Hodgkin lymphoma Gilead Sciences Terminated No outcome recorded
Phase 1/2 NCT02953782 Nov 2016 → Feb 2020 colorectal cancer Gilead Sciences Completed No outcome recorded
Phase 211 trials
Phase 2 NCT05829434 Mar 2024 → Aug 2028 acute myeloid leukemia, myelodysplastic syndrome Uwe Platzbecker Withdrawn No outcome recorded
Phase 2 NCT06046482 Nov 2023 → Aug 2024 head and neck squamous cell carcinoma M.D. Anderson Cancer Center Terminated No outcome recorded
Phase 2 NCT05929716 Sep 2023 → Mar 2026 B-cell non-Hodgkin lymphoma, large B-cell lymphoma M.D. Anderson Cancer Center Withdrawn No outcome recorded
Phase 2 NCT05835011 Jun → Aug 2023 myelodysplastic syndrome Astex Pharmaceuticals, Inc. Terminated No outcome recorded
Phase 2 NCT05330429 Jul 2022 → Jun 2024 colorectal cancer Gilead Sciences Terminated No outcome recorded
Phase 2 NCT04788043 Jun 2022 → Oct 2024 classic Hodgkin lymphoma Ranjana Advani Terminated No outcome recorded
Phase 2 NCT04958785 Dec 2021 → Oct 2024 triple-negative breast carcinoma Gilead Sciences Terminated No outcome recorded
Phase 2 NCT04892446 Nov 2021 → Apr 2024 plasma cell myeloma Gilead Sciences Terminated No outcome recorded
Phase 2 NCT04827576 Oct 2021 → Oct 2024 neoplasm Gilead Sciences Terminated No outcome recorded
Phase 2 NCT04854499 Sep 2021 → Oct 2024 head and neck squamous cell carcinoma Gilead Sciences Terminated No outcome recorded
Phase 33 trials
Phase 3 NCT05079230 Jul 2022 → Apr 2024 acute myeloid leukemia Gilead Sciences Terminated No outcome recorded
Phase 3 NCT04778397 Jul 2021 → Mar 2024 acute myeloid leukemia Gilead Sciences Terminated No outcome recorded
Phase 3 NCT04313881 Sep 2020 → Sep 2023 myelodysplastic syndrome Gilead Sciences Terminated No outcome recorded
Phase not stated1 trial
NCT05627466 acute myeloid leukemia Gilead Sciences No longer available No outcome recorded

Press releases naming this drug 7 releases

DateIssuerRelease
2023-08-21 Gilead Sciences Gilead Announces Partial Clinical Hold for Magrolimab Studies in AML gilead.com
2023-07-21 Gilead Sciences Gilead To Discontinue Phase 3 ENHANCE Study of Magrolimab Plus Azacitidine in Higher-Risk MDS gilead.com
2022-04-11 Gilead Sciences FDA Lifts Partial Clinical Hold on MDS and AML Magrolimab Studies gilead.com
2022-01-25 Gilead Sciences Gilead Announces Partial Clinical Hold for Studies Evaluating Magrolimab in Combination With Azacitidine gilead.com
2020-12-06 Gilead Sciences Magrolimab Demonstrates Clinical Responses in Ongoing Phase 1b Trial of Previously Untreated Acute Myeloid Leukemia Patients gilead.com
2020-09-15 Gilead Sciences Gilead’s Magrolimab, an Investigational Anti-CD47 Monoclonal Antibody, Receives FDA Breakthrough Therapy Designation for Treatment of Myelodysplastic Syndrome gilead.com
2020-05-29 Gilead Sciences Investigational Magrolimab in Combination With Azacitidine Demonstrates Durable Activity in Previously-Untreated Myelodysplastic Syndrome and Acute Myeloid Leukemia gilead.com

Evidence & citations 9 cited values

Every value below carries the sentence it was read from. 38 sources stand behind the page.

FieldValueCited text
Known as Magrolimab Magrolimab (ONO-7913) is an anti-cluster of differentiation 47 (CD47) monoclonal antibody.” PMID 41888930 Mar 2026
29

NCT05169944

NCT03869190

NCT04778410

NCT04854499

NCT05738161

NCT05829434

NCT05823480

NCT05330429

NCT04778397

NCT05079230

NCT03558139

NCT05807126

NCT04599634

NCT04827576

NCT05835011

NCT04313881

NCT04435691

NCT06046482

NCT05929716

NCT05627466

NCT02953509

NCT02953782

NCT04958785

NCT04541017

NCT03248479

NCT04892446

NCT04751383

NCT05367401

NCT04788043

Known as 5F9 “PURPOSE: To evaluate the safety, pharmacokinetics, and pharmacodynamics of Hu5F9-G4 (5F9), a humanized IgG4 antibody that targets CD47 to enable phagocytosis.” PMID 30811285 Feb 2019
Known as Hu5F9-G4 “Participants will receive atezolizumab and magrolimab (Hu5F9-G4) until unacceptable toxicity or loss of clinical benefit, as determined by the investigator after an integrated...” NCT03869190
4

NCT03527147

NCT02216409

NCT02678338

NCT03922477

Known as Mag magrolimab (Mag)” NCT04778410
Known as ONO-7913 “Magrolimab (ONO-7913) is an anti-cluster of differentiation 47 (CD47) monoclonal antibody.” PMID 41888930 Mar 2026
2

NCT06532344

NCT06540261

Action Inhibit “blocking monoclonal antibodies directed against CD47 enabled the phagocytosis” PMID 26390038 Sep 2015
Modality Monoclonal antibody “a humanized IgG4 antibody” PMID 30811285 Feb 2019
Route Intravenous “Hu5F9-G4 could be safely administered intravenously” PMID 26390038 Sep 2015
Target CD47 “targets CD47PMID 30811285 Feb 2019