drugset / Trial / NCT05941585
Mitoxantrone Hydrochloride Liposome Combined With Chemotherapy in Untreated de Novo Acute Myeloid Leukemia
RandomizedParallel-groupOpen-labelTreatment
Summary
The purpose of this study is to determine the safety, efficacy and pharmacokinetics of mitoxantrone hydrochloride liposome injection combined with chemotherapy in previously untreated de novo acute myeloid leukemia.
Timeline
- Start
- 2023-08-08
- Primary completion
- 2025-01-17
- Completion
- 2025-01-17
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Cytarabine | Small molecule | 100 mg/m2 | Intravenous |
| Subject | Cytarabine | Small molecule | 1000 mg/m2 | Intravenous |
| Subject | Homoharringtonine | Small molecule | 2 mg/m2 | Intravenous |
| Subject | Mitoxantrone | Small molecule | 24 mg/m2 | Intravenous |
| Subject | Mitoxantrone | Small molecule | 30 mg/m2 | Intravenous |
| Subject | Venetoclax | Small molecule | 400 mg | — |