drugset / Trial / NCT05941715
Faricimab for High-frequent Aflibercept Treated Neovascular Age-related Macular Degeneration
RandomizedParallel-groupTriple-blindTreatment
Summary
Study purpose: To evaluate if previously high-frequent (3-5 weekly) aflibercept treated neovascular age-related macular degeneration (nAMD) can be extended in their treatment interval when switched to faricimab. Primary objective: To assess the efficacy of faricimab compared to aflibercept in terms of durability at 32 weeks by extending treatment interval in previous high-frequent aflibercept treated nAMD.
Timeline
- Start
- 2023-07-04
- Primary completion
- 2024-09-25
- Completion
- 2025-02-26
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Aflibercept | Protein / enzyme biologic | 2 mg | Intravitreal |
| Subject | Faricimab | Monoclonal antibody | 6 mg | Intravitreal |