Modified Atkins Diet Versus Topiramate In Children With Epileptic Spasms Refractory To Hormonal Treatment: A Randomized Open-Label Study

Summary

This study has been planned to compare the efficacy and tolerability of topiramate, a commonly used second line agent, with modified Atkins diet in children with epileptic spasms refractory to hormonal treatment, in a randomized open label study.

Timeline

Start

2023-07-20

Primary completion

2024-09-30

Completion

2024-10-31

Publications

• Meena R, Roy Chowdhury S, Elwadhi A, Jain P, Mukherjee SB, Sharma S. Modified Atkins diet versus topiramate in young children with epileptic spasms refractory to steroids and vigabatrin: a randomised open-label trial. Seizure. 2025 Sep;131:405-412. doi: 10.1016/j.seizure.2025.08.011. Epub 2025 Aug 10.

Drugs

Indications