Sodium Chloride vs. Glucose Solute as a Volume Replacement Therapy During Decongestion in Acute Heart Failure

Summary

The aim of the study is to compare the differences in diuretic, natriuretic and clinical response to decongestion in patients receiving different replacement fluid regimens (0.9% sodium chloride vs 5% glucose) in acute heart failure.

Timeline

Start

2022-02-01

Primary completion

2024-04-01

Completion

2024-04-29

Publications

• Biegus J, Iwanek G, Testani J, Zymlinski R, Fudim M, Guzik M, Gajewski P, Ponikowski P. Sodium chloride versus glucose solute as a volume replacement therapy for more effective decongestion in acute heart failure (SOLVRED-AHF): A prospective, randomized, mechanistic study. Eur J Heart Fail. 2025 Nov;27(11):2442-2451. doi: 10.1002/ejhf.3708. Epub 2025 Jun 2.

Drugs

Indications