drugset / Trial / NCT05981365
Voxelotor CYP and Transporter Cocktail Interaction Study
Non-randomizedParallel-groupOpen-labelBasic science
Summary
This research study is examining multiple doses of voxelotor (a study drug intended for treatment of sickle cell disease) and how it interacts with additional substrates (substrates are drugs or other substances that are metabolized by cytochrome enzymes. The substrates used in this study are FDA approved medications). The study will help to determine the safety and tolerability of the study drugs taken together, as well as the pharmacokinetics (PK) on how your body processes and responds to the combination of the study drug and substrates. Although these drugs are FDA approved, their use in this study is experimental.
Timeline
- Start
- 2023-04-17
- Primary completion
- 2023-10-04
- Completion
- 2023-10-04
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Bupropion | Small molecule | — | — |
| Subject | Flurbiprofen | Small molecule | — | — |
| Subject | Furosemide | Other / unclassified | — | — |
| Subject | Metformin | Small molecule | — | — |
| Subject | Midazolam | Small molecule | — | — |
| Subject | Omeprazole | Other / unclassified | — | — |
| Subject | Repaglinide | Small molecule | — | — |
| Subject | Rosuvastatin | Small molecule | — | — |
| Subject | Voxelotor | Small molecule | — | — |