drugset / Trial / NCT05982522

IN10018 Combination Therapy in Previously-treated Solid Tumors

NCT05982522

Phase 1/2 Withdrawn InxMed (Shanghai) Co., Ltd.
RandomizedParallel-groupOpen-labelTreatment

Summary

This is a phase Ib/II, randomized, open-label, multicenter clinical trial to evaluate the antitumor activities, safety, tolerability and pharmacokinetics (PK) of IN10018 in combination with taxane and anti-PD-1/L1 monoclonal antibody in patients with locally advanced or metastatic solid tumors who have failed in or been intolerant to at least one line of standard therapy. This study will be firstly carried out in previously-treated non-small cell lung cancer (NSCLC) population,

Timeline

Start
2025-08-13
Primary completion
2026-12-31
Completion
2026-12-31

Drugs

EvaluationDrugModalityDoseRoute
Subject Ifebemtinib Small molecule Oral
Background Paclitaxel Small molecule 125 mg/m2 Intravenous
Background Tislelizumab Monoclonal antibody 200 mg Intravenous

Indications