Comparison Between Sevoflurane and Propofol for Maintenance of Sedation During ERCP
Summary
After approval of ethical committee of Sindh Institute of Urology \& Transplantation (SIUT), 86 patients were enrolled for the elective endoscopic retrograde cholangiopancreatography (ERCP). Randomization was done by a computer-generated randomization table. Patients were divided in two groups based on agents used for the research study. Both the groups were induced by injection midazolam 0.06 mg/kg body weight and injection nalbuphine 0.1 mg/kg body weight. In group A, anesthesia was maintained by Sevoflurane inhalation via nasal prongs with oxygen to achieve minimum alveolar concentration (MAC) approximately 0.25%. Whereas, in Group B propofol infusion at 50 ug/Kg/min started for maintenance of anaesthesia. Ketamine 0.5mg/kg intravenously was used to rescue the sedation level in both groups
Timeline
- Start
- 2022-01-05
- Primary completion
- 2022-11-25
- Completion
- 2022-11-25
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Propofol | Small molecule | 50 ug/kg | Intravenous |
| Subject | Sevoflurane | Other / unclassified | 4 % | Inhaled |
| Subject | Sevoflurane | Other / unclassified | 5 % | Inhaled |
Indications
No indication recorded.