drugset / Trial / NCT06004687

Effect of Acetaminophen Preemptive Analgesia on Postoperative Cognitive Function

NCT06004687

Phase 1/2 Unknown 100 enrolled Affiliated Hospital of Nantong University
RandomizedParallel-groupSingle-blindPrevention

Summary

Patients undergoing gastrointestinal tumor surgery are prone to delayed recovery and postoperative cognitive dysfunction due to greater trauma and longer operation time. Pre-analgesia can reverse the effects of nociceptive stimulation on recovery from general anesthesia and postoperative cognitive function. Intravenous injection of non-steroidal drugs can effectively reduce postoperative pain and the use of opioids. Therefore, This study selected acetaminophen mannitol injection for preemptive analgesia to observe the effects on anesthesia recovery time and postoperative cognitive function of patients undergoing gastrointestinal tumor surgery, providing new ideas for reducing cognitive dysfunction in patients undergoing gastrointestinal tumor surgery

Timeline

Start
2023-07-26
Primary completion
2024-05-30
Completion
2024-12-30

Drugs

EvaluationDrugModalityDoseRoute
Comparator Acetaminophen Small molecule 500 mg Intravenous

Indications