CSF Metabolomics and Glymphatic Function in Patients Receiving VP- Shunt Surgery.

Summary

In this randomized control study, the investigators intended to evaluate the influence of different anesthetics on postoperative cognitive dysfunction, neuroinflammation, CSF metabolomics, and glymphatic function in patients with normal pressure hydrocephalus for VP shunt surgery. The investigators assume that the use of dexmedetomidine infusion and proper anesthsia depth during general anesthesia, in addition to multi-model analgesia, might be helpful to enhance glymphatic function, reduce neuroinflammation, and decrease postoperative cognitive dysfunction.

Timeline

Start

2023-07-01

Primary completion

2026-06-30

Completion

2026-06-30

Drugs

Indications

No indication recorded.