CIRcadian Rhythms and CortisoL. Effects on Substrate Metabolism and Clock Gene Expression and Functioning

Summary

The aim of this project is to study the effects of exogenous glucocorticoid exposure on substrate metabolism, energy expenditure and correlates of circadian rhythmicity in healthy adults. The hypotheses are: Short-term high dose glucocorticoid exposure in healthy subjects disrupts: * The inherent circadian pattern of the respiratory exchange ratio and REE * Sleep quality, appetite and food intake * Clock gene expression and function in adipose tissue, skeletal muscle and blood leukocytes

Timeline

Start

2023-09-15

Primary completion

2024-04-13

Completion

2024-12-01

Drugs

Indications

No indication recorded.