LATe Cerclage in High-risk Pregnancies (LATCH)

Recruiting 329 enrolled Thomas Jefferson University

RandomizedParallel-groupOpen-labelTreatment

Summary

The goal of this clinical trial is to determine whether cervical cerclage reduces the risk of preterm birth in patients with a short transvaginal ultrasound (TVU) cervical length (CL) ≤25mm between 24 0/7-26 6/7 weeks.

Timeline

Start: 2023-11-10
Primary completion: 2028-10
Completion: 2029-02

Publications

Background Gulersen M, Lenchner E, Nicolaides KH, Otsuki K, Rust OA, Althuisius S, Bornstein E, Berghella V. Cervical cerclage for short cervix at 24 to 26 weeks of gestation: systematic review and meta-analysis of randomized controlled trials using individual patient-level data. Am J Obstet Gynecol MFM. 2023 Jun;5(6):100930. doi: 10.1016/j.ajogmf.2023.100930. Epub 2023 Mar 15.

Drugs

Evaluation	Drug	Modality	Dose	Route
Background	Progesterone	Other / unclassified	200 mg	Other

Indications

No indication recorded.