The Effects of Oxycodone Versus Sufentanil on Pain and Inflammatory Response After TACE

Summary

The purpose of this randomized, double-blind trial was to compare the effects of preemptive Oxycodone and sufentanil at the same dose on pain and inflammatory response after transcatheter arterial chemoembolization (TACE) of hepatocellular carcinoma. To study the effect of single dose intravenous injection of Oxycodone and sufentanil before TACE on inflammatory reaction after TACE; And (ii) evaluate the effects of different opioid drugs on pain and nausea/vomiting after TACE.

Timeline

Start

2023-08-07

Primary completion

2023-12-17

Completion

2023-12-25

Publications

• Wu WT, Xu BJ, Li B, Hang Y, Zu QQ, Zhou WZ, Liu S, Shi HB, Chen Y. Pre-emptive Oxycodone versus Sufentanil for Acute and Delayed Pain after Transcatheter Arterial Chemoembolization: A Randomized Controlled Trial with Inflammatory Biomarker Analysis. J Vasc Interv Radiol. 2026 May;37(5):108570. doi: 10.1016/j.jvir.2026.108570. Epub 2026 Jan 30.

Drugs

Indications