drugset / Trial / NCT06048705

Study of GSK3901961 In Previously Treated Advanced (Metastatic OR Unresectable) Synovial Sarcoma/ Myxoid/Round Cell Liposarcoma, and Previously Treated Metastatic Non-Small Cell Lung Cancer

NCT06048705 ↗

Phase 1 Terminated 7 enrolled Adaptimmune
NaSingle-groupOpen-labelTreatment

Summary

The primary purpose of this sub study is to assess the safety, tolerability and determine recommended Phase 2 dose (RP2D) of GSK3901961 in HLA A\*02:01, HLA-A\*02:05 and/or HLA A\*02:06 positive participants with New York esophageal squamous cell carcinoma (NY ESO 1) and/or Cancer testis antigen 2 (LAGE 1a) positive previously treated metastatic Non-Small Cell Lung Cancer (NSCLC) and previously treated, advanced (metastatic or unresectable) Synovial Sarcoma/ Myxoid/Round Cell Liposarcoma SS/MRCLS.

Timeline

Start
2021-03-09
Primary completion
2023-06-08
Completion
2023-06-08

Outcome

Outcome not reported

Stopped: “The study was terminated due to a change in GSK's R\&D priorities.”

Drugs

EvaluationDrugModalityDoseRoute
Subject GSK3901961 Cell therapy — —
Background Cyclophosphamide Other / unclassified — —
Background Fludarabine Small molecule — —

Indications