The Anti-fungal Effect of Miconazol Versus Miconazol-Loaded Chitosan Nanoparticles

Phase 1 Completed 80 enrolled Yasmine gamil

RandomizedParallel-groupTriple-blindTreatment

Summary

Objective: this study aimed to evaluate the therapeutic effects of topical application of miconazole and miconazole-loaded chitosan nanoparticles in treatment diabetic patients with oral candidiasis.

Timeline

Start: 2023-01-10
Primary completion: 2023-07-27
Completion: 2023-07-27

Outcome

Missed primary endpoint

paper The antifungal efficacy between the miconazole and miconazole-loaded chitosan nanoparticles (CS-MCZ) groups insignificant difference (P > 0.05) was observed. PMID 38321454 ↗

Publications

Gamil Y, Hamed MG, Elsayed M, Essawy A, Medhat S, Zayed SO, Ismail RM. The anti-fungal effect of miconazole and miconazole-loaded chitosan nanoparticles gels in diabetic patients with Oral candidiasis-randomized control clinical trial and microbiological analysis. BMC Oral Health. 2024 Feb 7;24(1):196. doi: 10.1186/s12903-024-03952-0.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Miconazole	Small molecule	—	Topical
Subject	POLIGLUSAM	Other / unclassified	—	Topical