drugset / Trial / NCT06124963

A Study of WX390 Combined With Toripalimab in Patients With Advanced Gastric-type Endocervical Adenocarcinoma With STK11 Mutations

NCT06124963

Phase 2 Recruiting 20 enrolled Shanghai Jiatan Pharmatech Co., Ltd
NaSequentialOpen-labelTreatment

Summary

The goal of this clinical trial is to evaluate the safety and preliminary efficacy of WX390 combined with Toripalimab in patients with advanced Gastric-type Endocervical Adenocarcinoma with STK11 mutations. The main questions it aims to answer are: * Pharmacokinetic (PK) characteristics of WX390 combined with Toripalimab treatment. * Safety and preliminary in combined therapy. Participants will be treated with WX390 orally and Toripalimab intravenously, and follow the efficacy and safety evaluation according to the protocol.

Timeline

Start
2023-08-25
Primary completion
2025-12-12
Completion
2026-12-09

Drugs

EvaluationDrugModalityDoseRoute
Subject Toripalimab Monoclonal antibody 240 mg Intravenous
Subject WX390 Unknown 0.9 mg Oral