drugset / Trial / NCT06126991
Organ Protective Effect of Cetirizine In Patients With Severe Burns
RandomizedParallel-groupSingle-blindTreatment
Summary
This prospective clinical trial aims to investigate the organ protective effects of cetirizine in patients with severe burns.
Timeline
- Start
- 2024-01-23
- Primary completion
- 2024-12-31
- Completion
- 2025-12-31
Publications
- Background Zhang M, Yang P, Yu T, Harmsen MC, Gao M, Liu D, Shi Y, Liu Y, Zhang X. Lytic cocktail: An effective method to alleviate severe burn induced hyper-metabolism through regulating white adipose tissue browning. Heliyon. 2022 Mar 17;8(3):e09128. doi: 10.1016/j.heliyon.2022.e09128. eCollection 2022 Mar.
- Results Wang J, Lu C, Zhang J, Gao M, Liu D, Yang P, Yu T, Wang X, Zhang X, Liu Y. LYTIC COCKTAIL ATTENUATES CATECHOLAMINE SURGE AFTER SEVERE BURNS BY BLOCKING HISTAMINE H1 RECEPTOR/PKA/CREB/TYROSINE HYDROXYLASE SIGNALING IN CHROMAFFIN CELLS. Shock. 2022 Aug 1;58(2):158-168. doi: 10.1097/SHK.0000000000001963. Epub 2022 Jul 24.
- Results Wang J, Lu C, Liu X, Zhang G, Zhang J, Gao M, Liu D, Zhang X, Liu Y. Histamine H1 receptor antagonist attenuates catecholamine surge and organ injury after severe burns. Front Endocrinol (Lausanne). 2023 Feb 9;14:1068925. doi: 10.3389/fendo.2023.1068925. eCollection 2023.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Cetirizine | Other / unclassified | 10 mg | Oral |
| Background | Fentanyl | Other / unclassified | 300 ug | — |
| Background | Midazolam | Small molecule | 50 mg | — |
Indications
No indication recorded.