ED90 of Bupivacaine After Lidocaine Test Dose With DPE and EPL
Summary
The primary objective of our study is to use a biased coin up-down allocation methodology to estimate the dose of bupivacaine required after the lidocaine test dose to achieve initial effective comfort in 90% of patients (post test-dose ED90) via the epidural (DPE or EPL) technique in women undergoing labor induction or augmentation; the investigators hypothesize that the investigators will be able to determine the post test-dose ED90 of bupivacaine for each technique with adequate precision to inform the optimal doses to study in a subsequent randomized trial comparing the analgesic effects of DPE vs. EPL. The investigators also hypothesize that the post test-dose ED90 of bupivacaine is lower with a DPE technique than with a conventional epidural technique.
Timeline
- Start
- 2023-12-01
- Primary completion
- 2027-06-30
- Completion
- 2027-06-30
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Bupivacaine | Other / unclassified | 22.5 mg | Other |
| Comparator | Bupivacaine | Other / unclassified | 25 mg | Other |
| Comparator | Bupivacaine | Other / unclassified | 27.5 mg | Other |
| Comparator | Bupivacaine | Other / unclassified | 30 mg | Other |
Indications
No indication recorded.