drugset / Trial / NCT06149130

Adebrelimab Combined With Dalpiciclib and Standard Endocrine Therapy for HR+/HER2 - Advanced Breast Cancer

NCT06149130

Phase 2 Recruiting 82 enrolled Tongji Hospital
NaSingle-groupOpen-labelTreatment

Summary

This is a prospective, single-arm, multicenter Phase II study of patients with advanced HR+/HER2- breast cancer who are untreated or have failed previous first-line endocrine therapy。The primary objective of this study was to explore the efficacy and safety of the PD-L1 inhibitor adebrelimab in combination with the CDK4/6 inhibitor Dalpiciclib and standard endocrine therapy in advanced HR+/ HER2-breast cancer.

Timeline

Start
2024-01-11
Primary completion
2025-11-30
Completion
2026-11-30

Drugs

EvaluationDrugModalityDoseRoute
Subject Adebrelimab Monoclonal antibody 1200 mg Intravenous
Background Dalpiciclib Small molecule 150 mg

Indications