Drugs / Adebrelimab
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Adebrelimab

also known as SHR-1316 · ADE · Adebrelimab Injection · Ariel

Monoclonal antibody targets CD274 via inhibition

Developed for
small cell lung carcinoma · non-small cell lung carcinoma · esophageal squamous cell carcinoma · hepatocellular carcinoma · cancer · malignant pancreatic neoplasm · breast cancer · biliary tract cancer
+48 more · colorectal cancer · intrahepatic cholangiocarcinoma · gastric cancer · gastroesophageal junction adenocarcinoma · hormone receptor-positive breast cancer · esophageal cancer · triple-negative breast carcinoma · gastric adenocarcinoma · head and neck squamous cell carcinoma · neoplasm · cervical cancer · gastroesophageal adenocarcinoma · cholangiocarcinoma · female breast carcinoma · nasopharyngeal carcinoma · urinary bladder carcinoma · biliary tract neoplasm · carcinoma · gastroesophageal cancer · Her2-receptor negative breast cancer · oral cavity squamous cell carcinoma · ovarian cancer · pancreatic ductal adenocarcinoma · rectal cancer · urothelial carcinoma · breast carcinoma · castration-resistant prostate carcinoma · digestive system carcinoma · esophageal small cell neuroendocrine carcinoma · gastric neoplasm · hypopharynx cancer · Langerhans cell histiocytosis · liver cancer · lung disorder · mature T-cell and NK-cell non-Hodgkin lymphoma · metastatic malignant neoplasm · metastatic malignant neoplasm in the brain · metastatic prostate carcinoma · neoplastic disease or syndrome · neuroendocrine carcinoma · neuroendocrine neoplasm · osteosarcoma · pancreatic adenocarcinoma · peripheral T-cell lymphoma, not otherwise specified · rectal carcinoma · rectum adenocarcinoma · thyroid cancer · urinary bladder cancer
Investigated by
Suzhou Suncadia Biopharmaceuticals Co., Ltd. · Jiangsu HengRui Medicine Co., Ltd. · Fudan University · Sun Yat-sen University · Tianjin Medical University Cancer Institute and Hospital · Jiangsu Hengrui Pharmaceutical Co., Ltd.
+127 more · Shanghai Hengrui Pharmaceutical Co., Ltd. · Peking University Cancer Hospital & Institute · Cancer Institute and Hospital, Chinese Academy of Medical Sciences · Harbin Medical University · Shanghai Shengdi Pharmaceutical Co., Ltd · Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University · Fujian Cancer Hospital · Tang-Du Hospital · The First Affiliated Hospital with Nanjing Medical University · Hansoh BioMedical R&D Company · Shanghai Zhongshan Hospital · The First Affiliated Hospital of Xiamen University · West China Hospital · Henan Cancer Hospital · Nanfang Hospital, Southern Medical University · Tongji Hospital · Jiangsu Hansoh Pharmaceutical Co., Ltd. · Zhejiang Cancer Hospital · Anhui Provincial Hospital · Atridia Pty Ltd. · First Affiliated Hospital Xi'an Jiaotong University · First Affiliated Hospital of Fujian Medical University · First Hospital of China Medical University · Fujian Medical University Union Hospital · Hebei Medical University Fourth Hospital · Jinling Hospital, China · Liaoning Cancer Hospital & Institute · Nanjing Tianyinshan Hospital · Ningbo Medical Center Lihuili Hospital · Peking Union Medical College Hospital · Ruijin Hospital · Shandong Suncadia Medicine Co., Ltd. · Shanghai Chest Hospital · Shanghai Pulmonary Hospital, Shanghai, China · Shanghai Regenelead Therapies Co., Ltd. · Shengjing Hospital · The First Affiliated Hospital of Zhengzhou University · Union Hospital, Tongji Medical College, Huazhong University of Science and Technology · Zhangzhou Municipal Hospital · Affiliated Hospital of Guangdong Medical University · Affiliated Hospital of Nantong University · Air Force Military Medical University, China · Baohui Han · Beijing 302 Hospital · Beijing Chest Hospital · Beijing Chest Hospital, Capital Medical University · Beijing Friendship Hospital · Cancer Hospital Chinese Academy of Medical Science, Shenzhen Center · Cancer Hospital of Guangxi Medical University · Changhai Hospital · Chen Chunyan · China Medical University, China · Chinese PLA General Hospital · Chongqing University Cancer Hospital · Feng Tian · Fujian Provincial Hospital · Gansu Provincial Cancer Hospital · Guangdong Provincial People's Hospital · Henan Provincial People's Hospital · Hospital of Stomatology, Wuhan University · Huazhong University of Science and Technology · HuiKai Li · Hunan Provincial Cancer Hospital · Jiang Long · Jiangmen Central Hospital · Jiangsu Cancer Institute & Hospital · Jilin Provincial Cancer Hospital · Jilin Provincial Tumor Hospital · Jin Xu · Jin Ying · Jinming Yu · Jinshazhou Hospital of Guangzhou University of Chinese Medicine · Jun Jia · Lei ZHAO · all 133 on the full record

Trials 265 · started per year

today
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20182019202020212022202320242025202620272028
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 03 trials
Phase 0 NCT06735508 Jan 2025 → Dec 2026 expected non-small cell lung carcinoma Guangdong Provincial People's Hospital Not yet recruiting No outcome recorded
Phase 0 NCT06156267 Jan 2024 → Apr 2026 overdue pancreatic adenocarcinoma Fudan University Not yet recruiting No outcome recorded
Phase 0 NCT06685653 ? → Nov 2026 expected non-small cell lung carcinoma Nanjing Tianyinshan Hospital Not yet recruiting No outcome recorded
Phase 118 trials
Phase 1 NCT07063407 Jul 2025 → Apr 2026 overdue small cell lung carcinoma Shanghai Hansoh Biomedical Co., Ltd Not yet recruiting No outcome recorded
Phase 1 NCT07009457 Jun 2025 → Sep 2027 expected small cell lung carcinoma Suzhou Suncadia Biopharmaceuticals Co., Ltd. Active not recruiting No outcome recorded
Phase 1 NCT06963502 May 2025 → Dec 2028 expected colorectal cancer, non-small cell lung carcinoma Jiangsu Hansoh Pharmaceutical Co., Ltd. Not yet recruiting No outcome recorded
Phase 1 NCT06902792 Feb → Aug 2025 overdue Langerhans cell histiocytosis Second Affiliated Hospital of Wenzhou Medical University Enrolling by invitation No outcome recorded
Phase 1 NCT06699576 Dec 2024 → Dec 2026 expected osteosarcoma, soft tissue sarcoma Hansoh BioMedical R&D Company Not yet recruiting No outcome recorded
Phase 1 NCT06594874 Oct 2024 → Oct 2026 expected non-small cell lung carcinoma Jiangsu Hansoh Pharmaceutical Co., Ltd. Not yet recruiting No outcome recorded
Phase 1 NCT06332170 Apr 2024 → May 2026 overdue neoplastic disease or syndrome Hansoh BioMedical R&D Company Recruiting No outcome recorded
Phase 1 NCT06336707 Apr 2024 → Apr 2026 overdue cancer Hansoh BioMedical R&D Company Recruiting No outcome recorded
Phase 1 NCT06225921 Dec 2023 → Jan 2025 esophageal squamous cell carcinoma West China Hospital Unknown No outcome recorded
Phase 1 NCT06181032 Dec 2023 → Feb 2029 expected biliary tract cancer First Affiliated Hospital of Fujian Medical University Recruiting No outcome recorded
Phase 1/231 trials
Phase 1/2 NCT07806058 Sep 2026 → Dec 2028 expected malignant pancreatic neoplasm Jiangsu HengRui Medicine Co., Ltd. Not yet recruiting No outcome recorded
Phase 1/2 NCT07736612 Aug 2026 → Aug 2028 expected malignant pancreatic neoplasm Zhejiang University Not yet recruiting No outcome recorded
Phase 1/2 NCT07615283 May 2026 → May 2030 expected mature T-cell and NK-cell non-Hodgkin lymphoma, peripheral T-cell lymphoma, not otherwise specified Sun Yat-sen University Not yet recruiting No outcome recorded
Phase 1/2 NCT07595172 Apr 2026 → Aug 2028 expected pancreatic ductal adenocarcinoma West China Hospital Recruiting No outcome recorded
Phase 1/2 NCT07392541 Jan 2026 → Jan 2028 expected biliary tract cancer Tongji Hospital Recruiting No outcome recorded
Phase 1/2 NCT07296341 Jan 2026 → Oct 2027 expected — Shanghai Hengrui Pharmaceutical Co., Ltd. Recruiting No outcome recorded
Phase 1/2 NCT07229586 Dec 2025 → Dec 2027 expected neoplasm Shanghai Hengrui Pharmaceutical Co., Ltd. Recruiting No outcome recorded
Phase 1/2 NCT07073534 Jul 2025 → Dec 2027 expected — Shanghai Hengrui Pharmaceutical Co., Ltd. Recruiting No outcome recorded
Phase 1/2 NCT07059221 Jul 2025 → Mar 2027 expected head and neck squamous cell carcinoma Suzhou Suncadia Biopharmaceuticals Co., Ltd. Recruiting No outcome recorded
Phase 1/2 NCT06840002 Mar 2025 → Dec 2026 expected ovarian cancer Suzhou Suncadia Biopharmaceuticals Co., Ltd. Recruiting No outcome recorded
Phase 2180 trials · 2 met primary
Phase 2 NCT07811375 Oct 2026 → Mar 2029 expected cervical cancer Anhui Provincial Hospital Not yet recruiting No outcome recorded
Phase 2 NCT07824882 Sep 2026 → Mar 2028 expected non-small cell lung carcinoma Hansoh BioMedical R&D Company Not yet recruiting No outcome recorded
Phase 2 NCT07751341 Sep 2026 → Dec 2027 expected esophageal squamous cell carcinoma Suzhou Suncadia Biopharmaceuticals Co., Ltd. Recruiting No outcome recorded
Phase 2 NCT07827053 Sep 2026 → Sep 2029 expected pancreatic ductal adenocarcinoma Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine Not yet recruiting No outcome recorded
Phase 2 NCT07865611 Sep 2026 → Dec 2028 expected urinary bladder carcinoma Tongji Hospital Not yet recruiting No outcome recorded
Phase 2 NCT07836543 Sep 2026 → Dec 2029 expected non-small cell lung carcinoma Ming Chen Not yet recruiting No outcome recorded
Phase 2 NCT07684040 Aug 2026 → Jul 2030 expected liver cancer Affiliated Hospital of Guangdong Medical University Not yet recruiting No outcome recorded
Phase 2 NCT07704645 Aug 2026 → Jun 2028 expected non-small cell lung carcinoma Suzhou Suncadia Biopharmaceuticals Co., Ltd. Not yet recruiting No outcome recorded
Phase 2 NCT07583550 Jul 2026 → Oct 2027 expected lung disorder Jiangmen Central Hospital Recruiting No outcome recorded
Phase 2 NCT07567326 Jul 2026 → Dec 2028 expected non-small cell lung carcinoma Peking University Cancer Hospital & Institute Not yet recruiting No outcome recorded
Show all 180 trials opens the full record — a long page
Phase 2/33 trials
Phase 2/3 NCT07454720 Mar 2026 → Nov 2032 expected — Suzhou Suncadia Biopharmaceuticals Co., Ltd. Recruiting No outcome recorded
Phase 2/3 NCT06879145 Apr 2025 → Dec 2031 expected urinary bladder carcinoma Suzhou Suncadia Biopharmaceuticals Co., Ltd. Recruiting No outcome recorded
Phase 2/3 NCT06335355 Mar 2024 → Oct 2028 expected non-small cell lung carcinoma Shanghai Shengdi Pharmaceutical Co., Ltd Not yet recruiting No outcome recorded
Phase 321 trials · 1 met primary
Phase 3 NCT07822542 Oct 2026 → May 2030 expected non-small cell lung carcinoma Jiangsu Hansoh Pharmaceutical Co., Ltd. Not yet recruiting No outcome recorded
Phase 3 NCT07679360 Sep 2026 → Dec 2030 expected triple-negative breast carcinoma Suzhou Suncadia Biopharmaceuticals Co., Ltd. Recruiting No outcome recorded
Phase 3 NCT07691762 Sep 2026 → Apr 2031 expected hepatocellular carcinoma Suzhou Suncadia Biopharmaceuticals Co., Ltd. Not yet recruiting No outcome recorded
Phase 3 NCT07522151 May 2026 → Dec 2029 expected gastroesophageal cancer Shanghai Shengdi Pharmaceutical Co., Ltd Recruiting No outcome recorded
Phase 3 NCT07560358 May 2026 → Dec 2029 expected non-small cell lung carcinoma Cancer Institute and Hospital, Chinese Academy of Medical Sciences Not yet recruiting No outcome recorded
Phase 3 NCT07464327 Mar 2026 → Dec 2028 expected non-small cell lung carcinoma Hansoh BioMedical R&D Company Not yet recruiting No outcome recorded
Phase 3 NCT07393542 Feb 2026 → Sep 2027 expected urothelial carcinoma Suzhou Suncadia Biopharmaceuticals Co., Ltd. Recruiting No outcome recorded
Phase 3 NCT07229625 Jan 2026 → Dec 2029 expected biliary tract cancer Suzhou Suncadia Biopharmaceuticals Co., Ltd. Recruiting No outcome recorded
Phase 3 NCT07238569 Dec 2025 → Dec 2029 expected nasopharyngeal carcinoma Sun Yat-sen University Not yet recruiting No outcome recorded
Phase 3 NCT07170995 Oct 2025 → Dec 2030 expected non-small cell lung carcinoma Suzhou Suncadia Biopharmaceuticals Co., Ltd. Recruiting No outcome recorded
Phase 42 trials
Phase 4 NCT06417606 May 2024 → Apr 2025 intrahepatic cholangiocarcinoma Zhiyong Huang Unknown No outcome recorded
Phase 4 NCT06192186 Dec 2023 → Dec 2025 gastric adenocarcinoma Yang Jianjun, PhD Unknown No outcome recorded
Phase not applicable7 trials
— NCT07388095 Feb 2026 → Feb 2027 expected esophageal squamous cell carcinoma Tianjin Medical University Cancer Institute and Hospital Not yet recruiting No outcome recorded
— NCT06893887 May 2025 → Dec 2027 expected hepatocellular carcinoma Nanjing Tianyinshan Hospital Recruiting No outcome recorded
— NCT06853678 Feb 2025 → Jul 2026 overdue small cell lung carcinoma Tianjin Medical University Cancer Institute and Hospital Recruiting No outcome recorded
— NCT06480864 Aug 2024 → Aug 2025 overdue small cell lung carcinoma Yunpeng Liu Recruiting No outcome recorded
— NCT06613113 Aug 2024 → Apr 2025 overdue colorectal cancer Ningbo Medical Center Lihuili Hospital Recruiting No outcome recorded
— NCT06420908 May 2024 → May 2026 esophageal squamous cell carcinoma Hebei Medical University Fourth Hospital Withdrawn No outcome recorded Stop: Enrollment
— NCT05132790 Sep 2023 → Dec 2024 overdue breast cancer Shengjing Hospital Active not recruiting No outcome recorded
Comparator or background therapy37 trials
Phase 1 NCT06350006 Background May 2024 → Dec 2027 expected — Shanghai Hengrui Pharmaceutical Co., Ltd. Recruiting No outcome recorded
Phase 1 NCT05942378 Background Jul 2023 → Sep 2025 cancer Fudan University Unknown No outcome recorded
Phase 1/2 NCT07239596 Background Jan 2026 → Dec 2030 expected renal cell carcinoma Suzhou Suncadia Biopharmaceuticals Co., Ltd. Recruiting No outcome recorded
Phase 1/2 NCT07136142 Background Sep 2025 → Feb 2027 expected cancer Jiangsu HengRui Medicine Co., Ltd. Recruiting No outcome recorded
Phase 1/2 NCT07105592 Background May 2025 → May 2027 expected head and neck squamous cell carcinoma Fudan University Recruiting No outcome recorded

News releases announcing trial results or a regulatory action · 6

DateIssuerRelease
2026-09-16 Jiangsu HengRui Medicine Co., Ltd. Results 2026 WCLC|恒瑞医药十余项肺癌领域研究亮相国际舞台 hengrui.com ↗
在54例疗效可评估患者中,初步ORR 87.0%,疾病控制率(DCR)98.1%。
2026-09-14 Jiangsu Hansoh Pharmaceutical Co., Ltd. Results WCLC 2026 | HANSOH PHARMA ANNOUNCES PROFFERED ORAL PRESENTATION OF PHASE I STUDY DATA OF HS-10370 COMBINED WITH ADEBRELIMAB AND CHEMOTHERAPY IN ADVANCED KRAS G12C-MUTATED NSCLC hspharm.com ↗
HS-10370 plus adebrelimab and chemotherapy demonstrated promising anti-tumor activity as first-line therapy for KRAS G12C-mutated advanced NSCLC, with a confirmed ORR of 81.5%; median PFS was not reached, and the 12-month PFS rate was 78.7%.
2026-06-03 Jiangsu HengRui Medicine Co., Ltd. Results 2026 ASCO口头报告|恒瑞医药Nectin-4 ADC创新药SHR-A2102联合阿得贝利单抗围手术期治疗肌层浸润性膀胱癌研究结果重磅发布 hengrui.com ↗
北京时间5月30日,恒瑞医药自主研发的新型Nectin‑4 ADC创新药SHR‑A2102联合PD‑L1抑制剂阿得贝利单抗用于肌层浸润性膀胱癌(MIBC)围手术期治疗(SHR‑A2102‑303研究)II期阶段的初步研究结果重磅公布。
2026-04-22 Jiangsu HengRui Medicine Co., Ltd. Results 2026 AACR口头报告︱恒瑞医药阿得贝利单抗围术期治疗可切除II-IIIB期非小细胞肺癌III期研究结果重磅亮相 hengrui.com ↗
研究结果显示 1 ,该疗法在主要终点病理缓解率(MPR)和无事件生存期(EFS)上均取得了统计学显著且具有临床意义的改善,安全性良好。
2026-04-20 Jiangsu Hansoh Pharmaceutical Co., Ltd. Results AACR 2026 | HANSOH PHARMA PRESENTED PHASE 1 RESULTS OF RISVUTATUG REZETECAN PLUS ADEBRELIMAB IN NON-SQUAMOUS NSCLC WITHOUT ACTIONABLE GENOMIC ALTERATIONS hspharm.com ↗
At AACR 2026, data from an expansion cohort of the phase 1 ARTEMIS-101 study evaluating risvutatug rezetecan plus adebrelimab in patients with previously treated nsq-NSCLC without AGAs were presented as an oral presentation.
2026-04-01 Jiangsu HengRui Medicine Co., Ltd. Results 2026 ELCC︱恒瑞医药4款创新药共7项肺癌研究亮相国际舞台 hengrui.com ↗
自2023年10月10日至2025年9月12日,共入组27例患者。

Evidence & citations 9 cited values

Every value below carries the sentence it was read from. 303 sources stand behind the page.

FieldValueCited text
Known as Adebrelimab “This is a prospective, multicenter, randomized, uncontrolled Phase II study to assess the efficacy and safety of adebrelimab in combination with chemotherapy with or without...” NCT06775275 ↗
264

“Lenvatinib(oral,12mg once daily if body weight ≥60Kg; Body weight \< 60Kg, 8mg/ day); Adebrelimab(intravenous drip,1200mg once every 3 weeks); GEMOX(intravenous...” NCT06417606 ↗

“a) Camrelizumab 200mg, b) Toripalimab 240mg, or c) Adebrelimab 1200mg will be started on day 1 of induction chemotherapy and given every 3 weeks for up to 12 cycles, or until...” NCT06675214 ↗

“This prospective, single-arm, multicenter clinical study aims to preliminarily evaluate the efficacy and safety of Trastuzumab Rezetecan combined with Adebrelimab as...” NCT07624201 ↗

“Participants will receive the combination of Fruquintinib and Adebrelimab within 3 weeks after completion of high and low dose radiotherapy on metastases until disease...” NCT06613113 ↗

“Phase III Study of SHR-8068 Combined With Adebrelimab and Chemotherapy Versus Tislelizumab Combined With Chemotherapy in the Treatment of Locally Advanced or Metastatic...” NCT07170995 ↗

“TPF (Paclitaxel micelles or albumin-bound paclitaxel 100 mg/m2, cisplatin 30 mg/m2, fluorouracil 200 mg/m2 IV drip + 1000 mg/m2 pump for 44 hours, leucovorin/calcium 200 mg) +...” NCT07469241 ↗

“Adebrelimab 1200 mg, repeated every 3 weeks, starting simultaneously with neoadjuvant chemotherapy and continuing for 1 year (including postoperative administration).” NCT06908668 ↗

“We aimed to assess the efficacy and safety of adebrelimab (SHR-1316), a novel anti-PD-L1 antibody, with standard chemotherapy as a first-line treatment for ES-SCLC.” PMID 35576956 ↗ May 2022

“After 4 cycles of concurrent chemoradiotherapy, the non-progressing subjects will continue to receive adebrelimab (1200 mg, IV, Q3W) maintenance therapy.” NCT07559786 ↗

“Immunotherapy consolidation began at the third cycle of chemotherapy: Adebrelimab 1200mg q3w to 2 year or disease progression” NCT06527898 ↗

Show 254 more sources

Known as ADE “intravenous infusion (IV) of Adebrelimab (ADE) (1200mg, IV, Q3W)” NCT06737913 ↗
Known as Adebrelimab Injection “-Generic Name: Adebrelimab Injection -Trade name: Ariel -English name: Adebrelimab Injection” NCT06902792 ↗
Known as Ariel “-Generic Name: Adebrelimab Injection -Trade name: Ariel -English name: Adebrelimab Injection” NCT06902792 ↗
Known as SHR-1316 “The therapeutic aim of Adebrelimab (SHR-1316) is to inhibit tumor growth by specifically blocking the binding of PD-1 to PD-L1 and terminating the immunosuppressive signals...” NCT06405061 ↗
48

“A Randomized, Double-blind, Multicenter Phase III Trial of Adebrelimab (SHR-1316) Plus S-1 and Oxaliplatin (SOX) Versus Placebo Plus S-1 and Oxaliplatin in the Perioperative...” NCT07522151 ↗

“The investigators will conduct a single-arm prospective study to evaluate the efficacy and safety of neoadjuvant therapy with adebrelimab (SHR-1316) and chemotherapy in...” NCT06178211 ↗

“Adebrelima(SHR-1316) is a recombinant humanized IgG4 antibody that binds efficiently and specifically to human and cynomolgus programmed cell death ligand 1 (PD-L1, CD274, or B7-H1)” NCT06375642 ↗

“Adebrelimab (SHR-1316) is a novel humanised IgG4 monoclonal antibody against PD-L1.” NCT07062328 ↗

“Adebrelimab (SHR-1316): injection, 600mg(12mL), intravenous infusion” NCT06439589 ↗

“adebrelimab (SHR-1316), a novel anti-PD-L1 antibody” PMID 35576956 ↗ May 2022

“Adebrelimab (SHR-1316) + Nab-paclitaxel + Cisplatin” NCT06869213 ↗

“Drug: SHR-1316 given intravenously (IV).” NCT04041011 ↗

“SHR-1316(Adebrelimab Injection)” NCT06237257 ↗

NCT07028281 ↗

Show 38 more sources

Action Inhibit “Anti-PD-L1 antibody” NCT04647357 ↗
Modality Monoclonal antibody “SHR-1316 is a humanized IgG4 monoclonal antibody” NCT03133247 ↗
Route Intravenous “SHR-1316 administrated intravenously(IV)” NCT03474289 ↗
Target CD274 “binds efficiently and specifically to human and cynomolgus programmed cell death ligand 1 (PD-L1, CD274, or B7-H1)” NCT06375642 ↗