Randomized Control Trial of Micronized Purified Flavonoid Fraction for Post Operative Treatment in Anal Fistula Surgery

Phase 4 Completed 106 enrolled Taipei Medical University Shuang Ho Hospital

RandomizedParallel-groupDouble-blindTreatment

Summary

The aim of this study is to evaluate the effect of micronized purified flavonoid fraction on postoperative symptoms after surgery of anorectal fistulas.

Timeline

Start: 2023-12-13
Primary completion: 2025-01-01
Completion: 2025-03-31

Outcome

Met primary endpoint

paper VAS scores were significantly lower in the MPFF group compared to the control group at multiple time points from 8 h post-surgery to day 7 PMID 41776089 ↗

paper frequency of dressing changes was reduced in the MPFF group relative to the control group PMID 41776089 ↗

paper statistically significant differences observed from day 4 onward (day 4, P = 0.036; day 5, P = 0.012; day 6, P = 0.012; day 7, P = 0.012) PMID 41776089 ↗

Publications

Tsai YW, Kiu KT, Chang TC. Efficacy of micronized purified flavonoid fraction in reducing pain after anal fistula surgery: a randomized controlled trial. Tech Coloproctol. 2026 Mar 3;30(1):36. doi: 10.1007/s10151-026-03298-5.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Micronized purified flavonoid fraction	Unknown	1000 mg	—