PK Effects of SHR4640 on Repaglinide and Midazolam, and the Impact of SHR4640 on QT Interval

Summary

The purpose of this study is to evaluate the PK effects of SHR4640 tablets on repaglinide and midazolam, as well as the effects of SHR4640 tablets on the QT interval in healthy subjects.

Timeline

Start

2024-01-04

Primary completion

2024-02-16

Completion

2024-02-16

Publications

• Cheng Y, Hu X, Pei Z, Zhang Z, Lin H, Feng S, Gao Z, Ma Y, Cao Z, Zhang Q, Zheng L, Zhang W, Shen K, Hu W. Evaluating the drug-drug interactions of SHR4640 on repaglinide and midazolam in healthy subjects. Expert Opin Drug Metab Toxicol. 2025 Jan-Feb;21(2):217-224. doi: 10.1080/17425255.2024.2428367. Epub 2024 Nov 14.

Drugs

Indications