Effect of Lidocaine Infusion on Neuraxial Opioid-induced Pruritus After Cesarean Section

Summary

The aim of this study is to assess the efficacy and potency of lidocaine infusion as a preventive measure on pruritus response after injection of 200 micro gram morphine with bupivacaine subarachnoid block, spinal anesthesia, in cesarean section.

Timeline

Start

2024-01-29

Primary completion

2024-04-30

Completion

2024-04-30

Outcome

Met primary endpoint

paper Pruritus occurred in 36.2% receiving lidocaine vs 73.1% in the control group PMID 41370909 ↗

paper Intravenous lidocaine infusion reduced the incidence and early severity of neuraxial morphine-induced pruritus after cesarean delivery without increased adverse events. PMID 41370909 ↗

Publications

• Eldemrdash AM, Alazhary MA, Hammad SS, Hemaida TS, Reda Ragheb AM, Shams GH, Dardeer TT, Zaher ZZ. Intravenous lidocaine infusion reduces intrathecal opioid-induced pruritus after cesarean delivery: a randomized controlled trial and proof-of-concept. Int J Obstet Anesth. 2026 Feb;65:104826. doi: 10.1016/j.ijoa.2025.104826. Epub 2025 Dec 2.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Lidocaine	Other / unclassified	1.5 mg/kg	Intravenous

Indications

No indication recorded.