Lacosamide Versus Topiramate in Migraine

Summary

Investigators aim to compare the effect of lacosamide versus topiramate in migraine by assessing the absolute reduction in MMD in each group, the percentage of patients who achieved ≥ 50% reduction in the monthly headache days frequency compared to the baseline frequency.

Timeline

Start

2024-02-01

Primary completion

2025-02-02

Completion

2025-02-25

Publications

• Results Lipton RB, Scher AI, Kolodner K, Liberman J, Steiner TJ, Stewart WF. Migraine in the United States: epidemiology and patterns of health care use. Neurology. 2002 Mar 26;58(6):885-94. doi: 10.1212/wnl.58.6.885.
• Results Lipton RB, Liberman JN, Kolodner KB, Bigal ME, Dowson A, Stewart WF. Migraine headache disability and health-related quality-of-life: a population-based case-control study from England. Cephalalgia. 2003 Jul;23(6):441-50. doi: 10.1046/j.1468-2982.2003.00546.x.
• Results Mushet GR, Miller D, Clements B, Pait G, Gutterman DL. Impact of sumatriptan on workplace productivity, nonwork activities, and health-related quality of life among hospital employees with migraine. Headache. 1996 Mar;36(3):137-43. doi: 10.1046/j.1526-4610.1996.3603137.x.
• Zeinhom MG, Khalil MFE, Almoataz M, Youssif TYO, Daabis AMA, Refat HM, Ebied AAMK, Georgy SS, Akl AZO, Ismaiel M, Ahmed SI, Eissa HF, Ibrahem AIDM, Hassan AM, Elshafei M, Egila AAE, Ahmed SR. Lacosamide versus topiramate in episodic migraine: a randomized controlled double-blinded trial. Ther Adv Neurol Disord. 2025 Dec 9;18:17562864251396529. doi: 10.1177/17562864251396529. eCollection 2025.

Drugs

Indications