drugset / Trial / NCT06247748
Influence of JY09 on Pharmacokinetics of Metformin , Rosuvastatin , and Digoxin and the QT Interval Study in Overweight Chinese Subjects
Non-randomizedCrossoverOpen-labelTreatment
Summary
This trial is conducted in china. The aim of the trial is as follows: * To assess the effect of multiple subcutaneous injections of JY09 injection on the pharmacokinetic (PK) profile of multiple oral doses of metformin hydrochloride tablets, a single oral dose of Rosuvastatin calcium tablets, or digoxin tablets in overweight Chinese subjects; * To assess the effect of multiple subcutaneous injections of JY09 injection on QT interval in overweight Chinese subjects.
Timeline
- Start
- 2023-10-19
- Primary completion
- 2024-04-15
- Completion
- 2024-04-15
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Digoxin | Other / unclassified | 0.25 mg | Oral |
| Subject | Exendin-4Fc fusion protein | Protein / enzyme biologic | 2.4 mg | Subcutaneous |
| Subject | Metformin | Small molecule | 0.5 g | Oral |
| Subject | Rosuvastatin | Small molecule | 10 mg | Oral |