Effectiveness of Antidiabetic Treatment Applied in Childhood Obesity

Phase 4 Completed 52 enrolled HÜMEYRA ACIKAN

NaSingle-groupOpen-labelTreatment

Summary

In our study, there are 33 healthy children with normal weight (control group) and 52 obese children who will be treated with metformin. To observe the efficacy of the 3-month treatment before and after metformin treatment, Zn, Zinc α-2 Glycoprotein (ZAG), Peroxisome proliferation activating receptor γ (PPARγ), Leptin (LEP) and Adiponectin (ADIPO) levels were compared, as well as anthropometric measurements and routine biochemistry tests.

Timeline

Start: 2019-11-17
Primary completion: 2021-08-20
Completion: 2021-10-27

Publications

Acikan H, Isik A, Sarikaya E, Muhtaroglu S, Hatipoglu N. The role of short-term metformin in regulating zinc and adipose tissue-derived biomarkers in children with obesity and insulin resistance. BMC Endocr Disord. 2026 Jan 7;26(1):36. doi: 10.1186/s12902-025-02159-w.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Metformin	Small molecule	1000 mg	—
Subject	Metformin	Small molecule	2000 mg	—

Indications

No indication recorded.