drugset / Trial / NCT06269484

A Phase IIb Study to Evaluate the Safety of Zibotentan/Dapagliflozin in Participants With Cirrhosis-ZEAL-UNLOCK

NCT06269484

Phase 2 Completed 73 enrolled AstraZeneca
RandomizedParallel-groupTriple-blindTreatment

Summary

This is a Phase IIb multicentre, randomised, double-blind, parallel-group, placebo-controlled study to evaluate the safety of zibotentan/dapagliflozin in combination as compared to zibotentan monotherapy as well as zibotentan/dapagliflozin and zibotentan monotherapy as compared to placebo in patients with cirrhosis.

Timeline

Start
2024-02-15
Primary completion
2024-12-11
Completion
2024-12-11

Drugs

EvaluationDrugModalityDoseRoute
Subject Dapagliflozin Small molecule 10 mg
Subject Zibotentan Small molecule

Indications