Metformin Use in Patients Undergoing Total Joint Replacement Surgery

Summary

The goal of this pilot, randomized, single-blind, placebo-controlled trial is to evaluate the feasibility of and provide preliminary information for a multi-center randomized controlled trial that will assess the effects of metformin on blood sugar control in patients after total hip or total knee replacement surgery. The primary objective of this study is to assess the feasibility of conducting a large, randomized trial with regards to timely recruitment, study drug administration, protocol adherence, and overall retention in patients undergoing total joint arthroplasty. Secondarily, the investigators aim to obtain preliminary estimates of group-specific outcome means and variances for primary and secondary outcomes of a larger future trial.

Timeline

Start

2024-06-27

Primary completion

2025-09-15

Completion

2025-09-15

Publications

• Morrell A, Shelofsky S, Hoffman H, McCallister C, Huff TW, Schabel KL, O'Glasser AY, Kagan RP. Perioperative metformin use in patients undergoing total joint replacement surgery: protocol for a randomised, placebo-controlled pilot study. BMJ Open. 2025 Apr 8;15(4):e091446. doi: 10.1136/bmjopen-2024-091446.

Drugs

Indications