drugset / Trial / NCT06300970
Efficacy of Artesunate-amodiaquine and Artemether-lumefantrine for Treatment of Plasmodium Falciparum Malaria in Liberia
Phase 4
Completed
352 enrolled
Centers for Disease Control and Prevention
Ministry of Health, Liberia · collab
Non-randomizedParallel-groupOpen-labelTreatment
Summary
To assess the efficacy of both first-line antimalarial medications used for the treatment of uncomplicated Plasmodium falciparum malaria infections in two geographic regions in Liberia.
Timeline
- Start
- 2022-08-09
- Primary completion
- 2023-08-16
- Completion
- 2023-08-16
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Artemether | Small molecule | 20 mg | Oral |
| Comparator | Artemether | Small molecule | 40 mg | Oral |
| Comparator | Artemether | Small molecule | 60 mg | Oral |
| Comparator | Artemether | Small molecule | 80 mg | Oral |
| Comparator | Artesunate | Small molecule | 25 mg | Oral |
| Comparator | Artesunate | Small molecule | 50 mg | Oral |
| Comparator | Artesunate | Small molecule | 100 mg | Oral |
| Comparator | Artesunate | Small molecule | 200 mg | Oral |
| Comparator | amodiaquine | Other / unclassified | 67.5 mg | Oral |
| Comparator | amodiaquine | Other / unclassified | 135 mg | Oral |
| Comparator | amodiaquine | Other / unclassified | 270 mg | Oral |
| Comparator | amodiaquine | Other / unclassified | 540 mg | Oral |
| Comparator | lumefantrine | Small molecule | 120 mg | Oral |
| Comparator | lumefantrine | Small molecule | 240 mg | Oral |
| Comparator | lumefantrine | Small molecule | 360 mg | Oral |
| Comparator | lumefantrine | Small molecule | 480 mg | Oral |