The Effects of Losartan on Attention Control: An Eye-tracking Study

Unknown 80 enrolled University of Electronic Science and Technology of China

RandomizedParallel-groupDouble-blindBasic science

Summary

The main aim of the present study is to investigate the effects of orally administered Losartan on bottom-up and top-down attentional control to socio-emotional stimuli by combining a validated saccade/antisaccade eye-tracking paradigm with a randomized between-subject placebo-controlled pharmacological trial design.

Timeline

Start: 2024-03-05
Primary completion: 2025-06-01
Completion: 2025-07-30

Publications

Han M, Fu K, Dong W, Wang J, Liu D, Zhuang Q, Xu X, Stefania F, Xu T, Kendrick KM, Yao D, Chang WC, Becker B. Angiotensin II regulates anxiety and social-affective top-down and bottom-up attention control in a sex-dependent manner. J Affect Disord. 2026 Jul 13:122254. doi: 10.1016/j.jad.2026.122254. Online ahead of print.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Losartan	Other / unclassified	50 mg	Oral

Indications

No indication recorded.