Losartan Modulates Neural Responses to Looming Visual Stimuli: An Eye-tracking Study

Unknown 80 enrolled University of Electronic Science and Technology of China

RandomizedParallel-groupDouble-blindBasic science

Summary

The main aim of the present study is to investigate the effects of orally administered losartan on the perception of time-to-collision of threatening and non-threatening stimuli by combining a validated looming fear eye-tracking paradigm with a randomized between-subject placebo-controlled pharmacological trial design.

Timeline

Start: 2024-03-05
Primary completion: 2025-06-01
Completion: 2025-07-30

Publications

Han M, Dong W, Fu K, Wang J, Xu Y, Zheng Y, Kendrick K, Ferraro S, Xu T, Yao D, Becker B. Vasopressin and angiotensin II pathways differentially modulate human fear response dynamics to looming threats. PLoS Biol. 2026 Feb 24;24(2):e3003668. doi: 10.1371/journal.pbio.3003668. eCollection 2026 Feb.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Losartan	Other / unclassified	50 mg	Oral

Indications

No indication recorded.