drugset / Trial / NCT06367374

MRD Guided Sonrotoclax and Zanubrutinib in Newly Diagnosed CLL/SLL

NCT06367374

Phase 2 Not yet recruiting 66 enrolled Institute of Hematology & Blood Diseases Hospital, China
NaSingle-groupOpen-labelTreatment

Summary

This is a single-arm, open-label study of sonrotoclax plus zanubrutinib with MRD-driven treatment duration in patients with previously untreated Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Lymphoma (SLL). The primary goal of this study is to evaluate the efficacy of MRD-guided zanubrutinib plus sonrotoclax for first-line CLL/SLL treatment.

Timeline

Start
2024-05-30
Primary completion
2030-02-28
Completion
2030-07-30

Drugs

EvaluationDrugModalityDoseRoute
Subject Sonrotoclax Other / unclassified 320 mg
Subject Zanubrutinib Small molecule 160 mg Oral