Drugs / Sonrotoclax
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Sonrotoclax

also known as BGB-11417 · BCL-2 indibitor · SON

Other / unclassified targets BCL2 via inhibition

Developed for
chronic lymphocytic leukemia/small lymphocytic lymphoma · mantle cell lymphoma · B-cell chronic lymphocytic leukemia · acute myeloid leukemia · neoplasm of mature B-cells · Waldenstrom macroglobulinemia · AL amyloidosis · B-cell neoplasm
+11 more · diffuse large B-cell lymphoma · large B-cell lymphoma · MALT lymphoma · mixed phenotype acute leukemia · myelodysplastic syndrome · myelodysplastic/myeloproliferative neoplasm · nodal marginal zone B-cell lymphoma · plasma cell myeloma · refractory plasma cell neoplasm · Richter transformation · splenic marginal zone lymphoma
Investigated by
BeOne Medicines · BeiGene · Ruijin Hospital · German CLL Study Group · Institute of Hematology & Blood Diseases Hospital, China · M.D. Anderson Cancer Center
+15 more · National Cancer Institute (NCI) · Alliance for Clinical Trials in Oncology · Canadian Cancer Trials Group · Christine Ryan · City of Hope Medical Center · Fred Hutchinson Cancer Center · French Innovative Leukemia Organisation · Massachusetts General Hospital · Peking University People's Hospital · Quotient Sciences · Shanghai Jiao Tong University School of Medicine · The First Affiliated Hospital of Soochow University · The First Affiliated Hospital with Nanjing Medical University · Tianjin Medical University Cancer Institute and Hospital · Yi Shuhua

Regulatory milestones approvals, filings & regulatory actions · 1 recorded

MilestoneJurisdictionBrandIndicationDateSentence it was read from
Approved US (FDA) BEQALZI 2026-05-13 fda.gov

Trials 39 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 18 trials
Phase 1 NCT07628881 Jun → Sep 2026 expected BeOne Medicines Recruiting No outcome recorded
Phase 1 NCT07548255 Apr 2026 → Mar 2029 expected mantle cell lymphoma Ruijin Hospital Not yet recruiting No outcome recorded
Phase 1 NCT07141511 Sep 2025 → Feb 2026 BeOne Medicines Completed No outcome recorded
Phase 1 NCT06859008 Aug 2025 → Jan 2029 expected MALT lymphoma, chronic lymphocytic leukemia/small lymphocytic lymphoma, diffuse large B-cell lymphoma, mantle cell lymphoma +2 City of Hope Medical Center Recruiting No outcome recorded
Phase 1 NCT06543043 Aug → Oct 2024 BeiGene Completed No outcome recorded
Phase 1 NCT05844111 May → Jun 2023 BeiGene Completed No outcome recorded
Phase 1 NCT04883957 Jul 2021 → Aug 2026 overdue neoplasm of mature B-cells BeiGene Active not recruiting No outcome recorded
Phase 1 NCT04277637 Mar 2020 → May 2027 expected neoplasm of mature B-cells BeOne Medicines Active not recruiting No outcome recorded
Phase 1/27 trials
Phase 1/2 NCT07687004 Aug 2026 → Aug 2027 expected plasma cell myeloma Institute of Hematology & Blood Diseases Hospital, China Not yet recruiting No outcome recorded
Phase 1/2 NCT07638787 Jun 2026 → Sep 2027 expected large B-cell lymphoma Ruijin Hospital Not yet recruiting No outcome recorded
Phase 1/2 NCT06697184 Jan 2025 → Nov 2029 expected B-cell chronic lymphocytic leukemia, mantle cell lymphoma BeOne Medicines Recruiting No outcome recorded
Phase 1/2 NCT06634589 Nov 2024 → Dec 2028 expected B-cell neoplasm BeOne Medicines Recruiting No outcome recorded
Phase 1/2 NCT05471843 Sep 2022 → Jul 2025 overdue mantle cell lymphoma BeiGene Active not recruiting No outcome recorded
Phase 1/2 NCT04973605 Sep 2021 → Nov 2026 expected refractory plasma cell neoplasm BeOne Medicines Recruiting No outcome recorded
Phase 1/2 NCT04771130 May 2021 → Feb 2028 expected acute myeloid leukemia, myelodysplastic syndrome, myelodysplastic/myeloproliferative neoplasm BeOne Medicines Recruiting No outcome recorded
Phase 219 trials
Phase 2 NCT07674810 Dec 2026 → Apr 2027 expected B-cell chronic lymphocytic leukemia M.D. Anderson Cancer Center Not yet recruiting No outcome recorded
Phase 2 NCT07508995 Sep 2026 → Jul 2031 expected B-cell chronic lymphocytic leukemia M.D. Anderson Cancer Center Not yet recruiting No outcome recorded
Phase 2 NCT07341191 Jun 2026 → Dec 2029 expected mantle cell lymphoma Canadian Cancer Trials Group Recruiting No outcome recorded
Phase 2 NCT07682415 Jun 2026 → Dec 2029 expected chronic lymphocytic leukemia/small lymphocytic lymphoma Yi Shuhua Not yet recruiting No outcome recorded
Phase 2 NCT07671378 Jun 2026 → Dec 2027 expected B-cell chronic lymphocytic leukemia The First Affiliated Hospital with Nanjing Medical University Recruiting No outcome recorded
Phase 2 NCT07548710 May 2026 → May 2027 expected acute myeloid leukemia Ruijin Hospital Recruiting No outcome recorded
Phase 2 NCT07573670 May 2026 → Dec 2027 expected mixed phenotype acute leukemia The First Affiliated Hospital of Soochow University Not yet recruiting No outcome recorded
Phase 2 NCT07335887 Jan 2026 → Feb 2028 expected AL amyloidosis Peking University People's Hospital Not yet recruiting No outcome recorded
Phase 2 NCT06547866 Dec 2025 → Dec 2028 expected Waldenstrom macroglobulinemia French Innovative Leukemia Organisation Not yet recruiting No outcome recorded
Phase 2 NCT06839053 Jun 2025 → Aug 2028 expected chronic lymphocytic leukemia/small lymphocytic lymphoma, mantle cell lymphoma Fred Hutchinson Cancer Center Recruiting No outcome recorded
Phase 35 trials
Phase 3 NCT07321652 Apr 2026 → Sep 2028 expected chronic lymphocytic leukemia/small lymphocytic lymphoma Alliance for Clinical Trials in Oncology Recruiting No outcome recorded
Phase 3 NCT07277231 Jan 2026 → Feb 2031 expected chronic lymphocytic leukemia/small lymphocytic lymphoma BeOne Medicines Recruiting No outcome recorded
Phase 3 NCT06943872 Jun 2025 → Sep 2029 expected chronic lymphocytic leukemia/small lymphocytic lymphoma BeOne Medicines Recruiting No outcome recorded
Phase 3 NCT06742996 Mar 2025 → Aug 2028 expected mantle cell lymphoma BeOne Medicines Recruiting No outcome recorded
Phase 3 NCT06073821 Nov 2023 → Feb 2032 expected chronic lymphocytic leukemia/small lymphocytic lymphoma BeOne Medicines Active not recruiting No outcome recorded

Evidence & citations 8 cited values

Every value below carries the sentence it was read from. 39 sources stand behind the page.

FieldValueCited text
Known as Sonrotoclax ClinicalTrials.gov intervention name — accepted as the source's own label NCT04271956
29

NCT06073821

NCT07674810

NCT04277637

NCT07335887

NCT06543043

NCT06854003

NCT06367374

NCT05952037

NCT06497062

NCT06742996

NCT07277231

NCT07628881

NCT07141511

NCT07682415

NCT06849713

NCT06839053

NCT07321652

NCT06634589

NCT06697184

NCT07638787

NCT07687004

NCT06637501

NCT07341191

NCT06859008

NCT07548710

NCT07548255

NCT07671378

NCT06943872

NCT04973605

Known as BCL-2 indibitor ClinicalTrials.gov intervention name — accepted as the source's own label NCT07573670
Known as BGB-11417 “A Phase 1b/2 Study of Sonrotoclax (BGB-11417) as Monotherapy and in Various Combinations With Dexamethasone Plus Carfilzomib, Dexamethasone Plus Daratumumab, and Dexamethasone...” NCT04973605
9

BGB-11417NCT04271956

NCT06547866

NCT05479994

NCT06463691

NCT05471843

NCT04771130

NCT07508995

NCT04883957

NCT05844111

Known as SON “For all the participants who are eligible for this trial, Sonrotoclax (SON): 20 mg/day on Day 1, 40 mg/day on Day 2, 80 mg/day on Day 3, 160 mg/day on Day 4, and 320 mg/day on...” NCT07548710
Action Inhibit “Sonrotoclax(BGB-11417), a Bcl-2 Inhibitor” NCT04271956
Modality Other / unclassified “A BCL 2 Protein Inhibitor” NCT06854003
Route Oral “Sonrotoclax 320 mg QD po” NCT04271956
Target BCL2 “Bcl-2 Inhibitor Sonrotoclax (BGB-11417)” NCT04277637