drugset / Trial / NCT07671378

A Study of MRD-Guided Zanubrutinib Plus Sonrotoclax in Treatment-Naïve, High-Risk CLL/SLL Patients

NCT07671378

NaSingle-groupOpen-labelTreatment

Summary

This study is a prospective, multicenter, open-label, single-arm phase II clinical trial evaluating the efficacy and safety of an MRD-guided, time-limited therapy with zanubrutinib combined with sonrotoclax in previously untreated high-risk CLL/SLL patients.

Timeline

Start
2026-06-01
Primary completion
2027-12-31
Completion
2030-12-31

Drugs

EvaluationDrugModalityDoseRoute
Subject Sonrotoclax Other / unclassified 320 mg Oral
Subject Zanubrutinib Small molecule 160 mg Oral