Topical TRanexamic Acid vs. Placebo on Acute Postoperative Pain Following DRF Fixation

Phase 4 Recruiting 90 enrolled University Health Network, Toronto

RandomizedParallel-groupQuadruple-blindTreatment

Summary

The goal of this study is to find out whether the use of topical tranexamic acid (TXA) into the surgical wound will result in less post-operative pain, less pain killer use, and better post-operative use of the wrist in people undergoing surgery for a wrist fracture compared to not using topical TXA (placebo).

Timeline

Start: 2025-08-13
Primary completion: 2026-12
Completion: 2027-12

Publications

Lameire DL, Noori A, Abbas A, Persitz J, Baltzer H, Collett E, Veillette C, Chan A, Paul R. The effect of topical TRanexamic Acid versus placebo on acute postoperative pain following Distal Radius fracture fixation: protocol for a randomised controlled trial at a quaternary care hand surgery centre - The TRADR study. BMJ Open. 2025 May 21;15(5):e095684. doi: 10.1136/bmjopen-2024-095684.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Tranexamic Acid	Small molecule	1 g	Topical

Indications

No indication recorded.