The Influence of Tramadol on Opioid-induced Bowel Dysfunction

Summary

Tramadol is a weak opioid and widely used to treat moderate to severe pain. Stronger opioids are known to inhibit gastrointestinal motility and secretion, however the effects of tramadol on gastrointestinal function remains less understood. The aim of this study was to determine to what degree tramadol causes opioid-induced bowel dysfunction by using an objective design to explore gastrointestinal transit, motility pattern, secretion, and colonic volume, in a group of healthy male volunteers.

Timeline

Start

2022-08-11

Primary completion

2023-05-15

Completion

2023-05-15

Drugs

Indications