drugset / Trial / NCT06420765
A Microneurography Study of NaV1.8 Inhibition in Healthy Adults
RandomizedParallel-groupQuadruple-blindBasic science
Summary
The purpose of this study is to determine the effects of Nav1.8 inhibition on activity-dependent slowing (ADS) of C-nociceptor nerve fibers, evoked action potential (AP) conduction velocity of C-nociceptor nerve fibers using VX-150, VX-993 and VX-548.
Timeline
- Start
- 2024-05-21
- Primary completion
- 2025-03-22
- Completion
- 2025-04-04
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Suzetrigine | Small molecule | — | Oral |
| Subject | VX-150 | Unknown | — | Oral |
| Subject | VX-993 | Unknown | — | Oral |
Indications
No indication recorded.