Efficacy and Resistance Mechanisms of IP in NSCLC With Leptomeningeal Metastases

Phase 2 Recruiting 220 enrolled Hunan Province Tumor Hospital Hunan Cancer Hospital · collab

NaSingle-groupOpen-labelTreatment

Summary

This is a prospective interventional study clinical study to investigate the efficacy and resistance mechanisms of intrathecal pemetrexed in patients with driver gene mutations advanced NSCLC with leptomeningeal metastases.

Timeline

Start: 2024-05-01
Primary completion: 2026-12-31
Completion: 2027-04-30

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Pemetrexed	Small molecule	50 mg	Intrathecal

Efficacy and Resistance Mechanisms of IP in NSCLC With Leptomeningeal Metastases

Summary

Timeline

Drugs

Indications