drugset / Trial / NCT06444594
Transient Receptor Potential Channels
RandomizedSingle-groupSingle-blindBasic science
Summary
Neurovascular signaling in the skin associated with stimulation of the transient receptor potential (TRP) channels. These channels are stimulated by both temperature and naturally occurring bioactive agents found in mint, chili peppers, garlic, etc. The aim of the study is to examine how topically applied TRP channel agonists including menthol, capsaicin and camphor impact neurovascular responses in the skin.
Timeline
- Start
- 2024-07-17
- Primary completion
- 2025-12-31
- Completion
- 2026-12-31
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Capsaicin | Small molecule | 0.05 % | Topical |
| Subject | Capsaicin | Small molecule | 1 % | Topical |
| Subject | Menthol | Small molecule | 4 % | Topical |
| Subject | Menthol | Small molecule | 10 % | Topical |
| Subject | camphor | Unknown | 0.6 % | Topical |
| Subject | camphor | Unknown | 5 % | Topical |
| Subject | camphor | Unknown | 20 % | Topical |