The Analgesic Efficacy of Vitamin B Complex in Critically Ill Obstetrics After Caesarean Section

Recruiting 100 enrolled Ain Shams University

RandomizedParallel-groupDouble-blindTreatment

Summary

We aim to investigate the value of vitamin B (B1, B6, B9, B12) on post-cesarean section analgesia in addition to the standard opioid-sparing multimodal regimen to achieve more robust analgesia with minimal side effects.

Timeline

Start: 2024-05-25
Primary completion: 2025-11-01
Completion: 2025-12-01

Publications

Background Neall G, Bampoe S, Sultan P. Analgesia for Caesarean section. BJA Educ. 2022 May;22(5):197-203. doi: 10.1016/j.bjae.2021.12.008. Epub 2022 Mar 8. No abstract available.
Background Deng XT, Han Y, Liu WT, Song XJ. B Vitamins Potentiate Acute Morphine Antinociception and Attenuate the Development of Tolerance to Chronic Morphine in Mice. Pain Med. 2017 Oct 1;18(10):1961-1974. doi: 10.1093/pm/pnw358.
Background Wang HJ, Zhang FC, Xu TW, Xu YC, Tian YQ, Wu YY, Xu JT, Hu S, Xu GY. DNMT1 involved in the analgesic effect of folic acid on gastric hypersensitivity through downregulating ASIC1 in adult offspring rats with prenatal maternal stress. CNS Neurosci Ther. 2023 Jun;29(6):1678-1689. doi: 10.1111/cns.14131. Epub 2023 Feb 27.
Background Kang WB, Chen YJ, Lu DY, Yan JZ. Folic acid contributes to peripheral nerve injury repair by promoting Schwann cell proliferation, migration, and secretion of nerve growth factor. Neural Regen Res. 2019 Jan;14(1):132-139. doi: 10.4103/1673-5374.243718.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	B1	Unknown	250 mg	Oral
Subject	B12	Other / unclassified	0.25 mg	Oral
Subject	B2	Unknown	15 mg	Oral
Subject	B6	Other / unclassified	150 mg	Oral
Subject	B9	Unknown	0.5 mg	Oral
Comparator	Acetaminophen	Small molecule	1 g	—

Indications

No indication recorded.