drugset / Trial / NCT06452511

Comparing the Effect of Metformin vs. Pep2dia as an Adjunct to Letrozole on Ovulation Induction and Pregnancy Outcomes in Overweight Women With PCOS

NCT06452511

Phase 0 Completed 100 enrolled Muhamed Ahmed Abdelmoaty Muhamed Alhagrasy
RandomizedParallel-groupOpen-labelTreatment

Summary

The goal of this clinical trial is to compare the effects of Metformin versus Pep2dia as adjunct treatments to Letrozole on ovulation induction and pregnancy outcomes in overweight women with polycystic ovary syndrome (PCOS). The main questions it aims to answer are: Does Metformin improve ovulation rates more effectively than Pep2dia when used alongside Letrozole? Does Pep2dia enhance pregnancy outcomes compared to Metformin in this patient population? Participants will: Receive either Metformin or Pep2dia in addition to Letrozole. Undergo regular monitoring for ovulation and pregnancy outcomes. Researchers will compare the Metformin group to the Pep2dia group to see if there is a significant difference in ovulation and pregnancy rates between the two treatments.

Timeline

Start
2024-08-01
Primary completion
2025-03-25
Completion
2025-03-25

Drugs

EvaluationDrugModalityDoseRoute
Comparator Metformin Small molecule
Comparator pep2dia Peptide