drugset / Trial / NCT06514898
Adoptive T Cell Therapy, DC Vaccines, and Hematopoietic Stem Cells Combined With Immune checkPOINT Blockade in Patients With Medulloblastoma
Phase 1
Recruiting
12 enrolled
University of Florida
Children's National Research Institute · collab
NaSingle-groupOpen-labelTreatment
Summary
This is a pilot study in a small number of children and young adults with suspected recurrent/progressive medulloblastoma (MB) looking at the feasibility and safety of adoptive cell therapy plus PD-1 blockade.
Timeline
- Start
- 2025-05-05
- Primary completion
- 2027-09-01
- Completion
- 2028-12-01
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Pembrolizumab | Monoclonal antibody | — | Intravenous |
| Subject | TTRNA-DC vaccines | Vaccine | — | Other |
| Subject | TTRNA-xALT | Cell therapy | — | Intravenous |
| Background | Td vaccine | Vaccine | 1 unknown | Intramuscular |
| Background | Td vaccine | Vaccine | 5 unknown | Intramuscular |
| Background | autologous HSCs | Cell therapy | 2 unknown | Intravenous |
| Background | sargramostim | Protein / enzyme biologic | 150 ug | Other |