ALPP CAR-T Cells for ALPP-Positive Advanced Solid Tumors

Summary

Alkaline phosphatase (ALP) is a membrane-bound glycoprotein that catalyzes the hydrolysis of phosphates at alkaline pH values. As one of the earliest discovered oncofetal antigens, ALP has emerged as a significant biomarker for various malignant tumors, such as ovarian cancer, breast cancer, trophoblastic tumors, germ cell tumors, endometrial cancer, testicular tumors, cervical intraepithelial neoplasia, and gastrointestinal tumors.

Timeline

Start

2018-01-01

Primary completion

2025-01-30

Completion

2025-07-30

Drugs

Indications