Dexmedetomidine for Attenuation of Pressor Response

NCT06592027 ↗

Phase 4 Completed 60 enrolled Theodor Bilharz Research Institute

RandomizedParallel-groupQuadruple-blindTreatment

Summary

Direct laryngoscopy and tracheal intubation are usually associated by hemodynamic changes due to increased sympathoadrenal activity which could precipitate serious negative effects in compromised patients . The pressor response could be blunted by dexmedetomidine which is a selective alpha 2 agonist which might provide hemodynamic stability during tracheal intubation.

Timeline

Start: 2024-02-01
Primary completion: 2024-05-01
Completion: 2024-05-30

Publications

Background Misra S, Behera BK, Mitra JK, Sahoo AK, Jena SS, Srinivasan A. Effect of preoperative dexmedetomidine nebulization on the hemodynamic response to laryngoscopy and intubation: a randomized control trial. Korean J Anesthesiol. 2021 Apr;74(2):150-157. doi: 10.4097/kja.20153. Epub 2020 May 20.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Dexmedetomidine	Other / unclassified	0.5 ug/kg	Intravenous
Comparator	Dexmedetomidine	Other / unclassified	1 ug/kg	Intravenous

Indications

No indication recorded.