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drugset / Trial / NCT06628544

Trained Immunity in Fungal Infection and Its Mechanism

NCT06628544 ↗

Phase 0 Completed 79 enrolled Zhongnan Hospital
RandomizedParallel-groupOpen-labelBasic science

Summary

Investigator vaccinated 76 healthy BCG-naive participant with BCG, while 3 participants received. Half of BCG-vaccinated participants (n = 38) received an incremental dose of metformin for 6 days (up to 1,000 mg twice daily on day 6). On the day 0 (total 20; n = 10 for BCG vaccination, n = 10 for BCG vaccination plus taking metformin), day 14 (total 30; n=15 for BCG vaccination, n = 15 for BCG vaccination plus taking metformin), day 90 (total 26; n = 13 for BCG vaccination, n=13 for BCG vaccination plus taking metformin) of BCG vaccination, PBMCs were isolated, restimulated with C. albicans or Mycobacterium tuberculosis.

Timeline

Start
2020-09-01
Primary completion
2023-08-31
Completion
2023-12-01

Drugs

EvaluationDrugModalityDoseRoute
Subject BCG Unknown — —
Subject Metformin Small molecule 1000 mg —

Indications

No indication recorded.