drugset / Trial / NCT06662253

Anti-Xa Guided Dosing of Low Molecular Weight Heparin for Prevention of Venous Thromboembolism Following Traumatic Injury: a Multicentre Pilot Randomized Trial

NCT06662253

Phase 2/3 Not yet recruiting 150 enrolled Alexandre Tran
RandomizedSingle-groupOpen-labelPrevention

Summary

This multicentre pilot trial will assess the feasibility of a full-scale, randomized trial to determine whether bloodwork guided dosing of blood thinners reduces the risk of clotting in high-risk trauma patients. Patients will receive either standard of care dosing or dosing with adjustments based on bloodwork to achieve a minimum therapeutic threshold.

Timeline

Start
2025-01
Primary completion
2026-06
Completion
2026-09

Drugs

EvaluationDrugModalityDoseRoute
Subject Enoxaparin sodium Other / unclassified 0.5 mg/kg
Comparator Heparin Other / unclassified