Lymphocyte-Sparing And Radio-Immunotherapy in Head and Neck Carcinoma

Phase 3 Recruiting 460 enrolled Centre Leon Berard

RandomizedFactorialOpen-labelTreatment

Summary

The aim of this study is to investigate the effect of ATRA (Vesanoid) and the effect of tailored radiotherapy in patients with squamous cell carcinoma of the oropharynx, larynx or hypopharynx.

Timeline

Start: 2025-02-20
Primary completion: 2029-01
Completion: 2029-01

Publications

Gau M, Alfaraj FA, Huang SH, O'Sullivan B, Su J, Xu W, Hamilton SN, Maletta A, Salman O, McInerney M, Javed A, Sanz-Garcia E, Bratman S, Hahn E, Hope A, Kim JJ, Malik N, McPartlin A, Tsai CJ, Waldron J, Yao CMKL, de Almeida JR, Hosni A. Unilateral vs bilateral neck irradiation: The importance of careful patient selection in tailoring radiation therapy for lateralized palatine-tonsil and non-palatine-tonsil oropharyngeal carcinoma. Radiother Oncol. 2025 Sep;210:111049. doi: 10.1016/j.radonc.2025.111049. Epub 2025 Jul 19.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Tretinoin	Small molecule	150 mg/m2	Oral
Background	Cetuximab	Monoclonal antibody	250 mg/m2	Intravenous
Background	Cisplatin	Other / unclassified	40 mg/m2	Intravenous
Background	Cisplatin	Other / unclassified	100 mg/m2	Intravenous

Lymphocyte-Sparing And Radio-Immunotherapy in Head and Neck Carcinoma

Summary

Timeline

Publications

Drugs

Indications